
Jump to Side Effects - Isotretinoin has many side effects but most are predictable and to specifically enquire about related symptoms at each clinic vlfvg.use effect: Incidence up to. Aug 3, - Isotretinoin (better known as Accutane) has a scary reputation. serious side effects, however, it is safe when properly used and when patients. Many of the side effects and adverse reactions seen in patients receiving Accutane (isotretinoin) are similar to those described in patients taking very high doses of vitamin A (dryness of the skin and mucous membranes, eg, of the lips, nasal passage, and eyes).